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KMID : 0363320090300020257
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Journal of Korean Oriental Internal Medicine
2009 Volume.30 No. 2 p.257 ~ p.269
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The Effects of Supungsunki-hwan on High Fat, High Carbohydrate Diet-induced Obese Type 2 Diabetic Mouse Model
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Park Jong-seol
Lee Byung-Cheol
Doo Ho-Kyung
Ahn Young-Min
Ahn Se-Young
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Abstract
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Objective: Obesity is an important cause of diabetes, and lipotoxicity causes insulin resistance. Recently a lot of research is being done on PPAR-. TNF-. adiponectin, and leptin, which are important obesity related factors. In this study, we investigated the effects of Supungsunki-hwan on high fat. high carbohydrate diet-induced obese type 2 diabetic mouse models.
Methods: Diabetes was induced in ICR male mouse (305g) with Surwit’s high fat, high sucrose diet. Mice were divided into 4 groups(n=10) of Normal. Control. Supungsunkj-hwan group. and acarbose group. The Supungsunki-hwsn group was given 10% Supungsunkj-hwan in their diet. and the acarbose group was given 0.5% acarbose in their diet. After 6 weeks. body weight. food intake, FBS and OGTT. lipid profile and liver enzymes, epididymal fat weight, and gene expression of leptin, adiponectin, TNF- and PPAR- were measured. Leptin. adiponectin. tumor necrosis factor(TNF)- and peroxisome proliferator-activated receptor (PPAR)- were evaluated by reverse transcription-polymerase chain reaction.
Results: Supungsunkj-hwan increased the gene expression of PPAR-, which reduces lipotoxicity and insulin resistance. Supungsunkj-hwan also significantly reduced triglyceride. AST. ALT serum levels. and 1 hour oral glucose tolerance levels.
Conclusion: These results show that Supungsunkj-hwan improves insulin resistance in the liver and muscles, by reducing triglyceride levels and lipotoxicity through increased PPAR- gene expression. This is supported by the fact that Supungsunkj-hwan significantly reduces 1 hour oral glucose tolerance levels. Therefore we suggest that Supungsunkj-hwan would be an effective treatment for obese type 2 diabetic patients.
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KEYWORD
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Supungsunki-hwan, insulin resistance, lipotoxicity, PPAR-, Type 2 diabetes, Obesity
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